Status Ailments are negative effects that can impair any of the main characters in a variety of ways. They are caused by specific enemy attacks and must be healed by Akiko's +Kit. The status ailments in Sweet Home include:
- Curse (Crs) - Every step costs 1 Pray Point.
- Frozen (Froze) - Character leaves their party and cannot move until healed.
- Scared (Fear) - Begins 10 steps after battle. Character leaves their party, cannot move until healed, and loses 1 HP every few seconds.
- Poison (Pn) - Every step costs 1 HP.
- Strong Poison (XPnX) - Begins immediately after battle. Character leaves their party, cannot move until healed, and loses 1 HP every few seconds.
- Stunned - Occurs in battle only, characterized by the screen gaining a blue tint. Character cannot move. All attacks from other characters will target the stunned character instead. Can be cured by praying. If the player runs away from battle instead of praying, the afflicted character will be frozen.
- Death - Character leaves current party and can no longer do anything. Cannot be healed.
- Caused by: HP reaching 0.